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Disseminated molluscum contagiosum in a HIV-positive child. Improvement after therapy with 5% imiquimod


Theiler, M; Kempf, W; Kerl, K; French, L E; Hofbauer, G F L (2011). Disseminated molluscum contagiosum in a HIV-positive child. Improvement after therapy with 5% imiquimod. Journal of Dermatological Case Reports, 5(2):19-23.

Abstract

BACKGROUND:

Molluscum contagiosum (MC) is a frequent and usually benign cutaneous infection with molluscum contagiosum virus (MCV), affecting mainly children and young sexually active adults. With the emergence of HIV/AIDS, a new patient group at risk has been identified with often extensive skin involvement and recalcitrant disease.
MAIN OBSERVATIONS:

We report a case of a girl with connatal HIV-infection, suffering from extensive, disseminated MC. Due to multi-resistance, an effective antiretroviral therapy could not be established for years, rendering an effective treatment of MC by established treatment options virtually impossible. An off-label use of imiquimod showed a marked improvement of lesion counts in this patient, whereas a complete clearance could only be achieved once effective antiretroviral therapy was introduced.
CONCLUSIONS:

We believe that imiquimod may represent a valuable treatment option for molluscum contagiosum especially in the context of marked immunosuppression, where sensitive areas like the face and neck are often involved and scarring must be avoided.

BACKGROUND:

Molluscum contagiosum (MC) is a frequent and usually benign cutaneous infection with molluscum contagiosum virus (MCV), affecting mainly children and young sexually active adults. With the emergence of HIV/AIDS, a new patient group at risk has been identified with often extensive skin involvement and recalcitrant disease.
MAIN OBSERVATIONS:

We report a case of a girl with connatal HIV-infection, suffering from extensive, disseminated MC. Due to multi-resistance, an effective antiretroviral therapy could not be established for years, rendering an effective treatment of MC by established treatment options virtually impossible. An off-label use of imiquimod showed a marked improvement of lesion counts in this patient, whereas a complete clearance could only be achieved once effective antiretroviral therapy was introduced.
CONCLUSIONS:

We believe that imiquimod may represent a valuable treatment option for molluscum contagiosum especially in the context of marked immunosuppression, where sensitive areas like the face and neck are often involved and scarring must be avoided.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:June 2011
Deposited On:12 Feb 2012 10:18
Last Modified:05 Apr 2016 15:33
Publisher:Spejaliści Dermatolodzy, PL
ISSN:1898-7249 (E)
Publisher DOI:https://doi.org/10.3315/jdcr.2011.1066
PubMed ID:21894250
Permanent URL: https://doi.org/10.5167/uzh-58272

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