Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5835
Lesch, K P; Timmesfeld, N; Renner, T J; Halperin, R; Röser, C; Nguyen, T T; Craig, D W; Romanos, J; Heine, M; Meyer, J; Freitag, C; Warnke, A; Romanos, M; Schäfer, H; Walitza, S; Reif, A; Stephan, D A; Jacob, C (2008). Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. Journal of Neural Transmission, 115(11):1573-1585.
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A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing ~500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Center for Child and Adolescent Psychiatry|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||29 Dec 2008 12:00|
|Last Modified:||28 Nov 2013 01:47|
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