Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5836

Haid, Clemens; Kaps, Simone P; Gönczi, Enikő; Hässig, Michael; Metzler, Alfred; Spiess, Bernhard M; Richter, Marianne (2007). Pretreatment with feline interferon omega and the course of subsequent infection with feline herpesvirus in cats. Veterinary Ophthalmology, 10(5):278-284.

[img] PDF - Registered users only
View at publisher


Objective:Recombinant feline interferon omega (rFeIFN-ω), a type I IFN, may have the potential to limit virus replication and associated clinical signs when administered early on in the course of feline herpesvirus type 1 (FHV-1) infection and reactivation, respectively. The effect of rFeIFN-ω pretreatment on the course of subsequent FHV-1 infection in cats was investigated.
Animals studied: Nine SPF cats were divided into an IFN group (n=5) and a control-group (n=4).
Procedures: The IFN group was pretreated for 2 days with 10 000 units rFeIFN-ω twice aday topically into both eyes and 20 000 units rFeIFN-ω once a day orally, whereas the control group was mock-treated. Subsequently all cats were infected with FHV-1. Samples for FHV-1 DNA detection and quantitation, virus isolation, and titration of FHV-1 antibodies were collected. Clinical and ocular signs were recorded and scored.
Results: Courses of median individual clinical and ocular scores and virus load did not differ significantly between both groups using for repeated measurements. Analysis (Anova)of each individual ocular parameter revealed significantly high scores for epithelial keratitis (P=0.016) in the IFN group compared to the control group. Periods of virus shedding did not differ significantly between both groups using the Wilcoxon rank sum test.
Conclusions: Results indicated a lack of beneficial effects of rFeIFN-ω pretreatment in the course of primary FHV-1 infection in cats.


16 citations in Web of Science®
17 citations in Scopus®
Google Scholar™



2 downloads since deposited on 20 Mar 2009
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:cytokine, eye, feline, FHV-1, herpes, interferon, rhinotracheitis
Date:May 2007
Deposited On:20 Mar 2009 14:32
Last Modified:02 Jun 2016 07:53
Publisher DOI:10.1111/j.1463-5224.2007.00550.x
PubMed ID:17760705

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page