UZH-Logo

Pretreatment with feline interferon omega and the course of subsequent infection with feline herpesvirus in cats


Haid, Clemens; Kaps, Simone P; Gönczi, Enikő; Hässig, Michael; Metzler, Alfred; Spiess, Bernhard M; Richter, Marianne (2007). Pretreatment with feline interferon omega and the course of subsequent infection with feline herpesvirus in cats. Veterinary Ophthalmology, 10(5):278-284.

Abstract

Objective:Recombinant feline interferon omega (rFeIFN-ω), a type I IFN, may have the potential to limit virus replication and associated clinical signs when administered early on in the course of feline herpesvirus type 1 (FHV-1) infection and reactivation, respectively. The effect of rFeIFN-ω pretreatment on the course of subsequent FHV-1 infection in cats was investigated.
Animals studied: Nine SPF cats were divided into an IFN group (n=5) and a control-group (n=4).
Procedures: The IFN group was pretreated for 2 days with 10 000 units rFeIFN-ω twice aday topically into both eyes and 20 000 units rFeIFN-ω once a day orally, whereas the control group was mock-treated. Subsequently all cats were infected with FHV-1. Samples for FHV-1 DNA detection and quantitation, virus isolation, and titration of FHV-1 antibodies were collected. Clinical and ocular signs were recorded and scored.
Results: Courses of median individual clinical and ocular scores and virus load did not differ significantly between both groups using for repeated measurements. Analysis (Anova)of each individual ocular parameter revealed significantly high scores for epithelial keratitis (P=0.016) in the IFN group compared to the control group. Periods of virus shedding did not differ significantly between both groups using the Wilcoxon rank sum test.
Conclusions: Results indicated a lack of beneficial effects of rFeIFN-ω pretreatment in the course of primary FHV-1 infection in cats.

Objective:Recombinant feline interferon omega (rFeIFN-ω), a type I IFN, may have the potential to limit virus replication and associated clinical signs when administered early on in the course of feline herpesvirus type 1 (FHV-1) infection and reactivation, respectively. The effect of rFeIFN-ω pretreatment on the course of subsequent FHV-1 infection in cats was investigated.
Animals studied: Nine SPF cats were divided into an IFN group (n=5) and a control-group (n=4).
Procedures: The IFN group was pretreated for 2 days with 10 000 units rFeIFN-ω twice aday topically into both eyes and 20 000 units rFeIFN-ω once a day orally, whereas the control group was mock-treated. Subsequently all cats were infected with FHV-1. Samples for FHV-1 DNA detection and quantitation, virus isolation, and titration of FHV-1 antibodies were collected. Clinical and ocular signs were recorded and scored.
Results: Courses of median individual clinical and ocular scores and virus load did not differ significantly between both groups using for repeated measurements. Analysis (Anova)of each individual ocular parameter revealed significantly high scores for epithelial keratitis (P=0.016) in the IFN group compared to the control group. Periods of virus shedding did not differ significantly between both groups using the Wilcoxon rank sum test.
Conclusions: Results indicated a lack of beneficial effects of rFeIFN-ω pretreatment in the course of primary FHV-1 infection in cats.

Citations

16 citations in Web of Science®
17 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

2 downloads since deposited on 20 Mar 2009
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:cytokine, eye, feline, FHV-1, herpes, interferon, rhinotracheitis
Language:English
Date:May 2007
Deposited On:20 Mar 2009 14:32
Last Modified:02 Jun 2016 07:53
Publisher:Wiley-Blackwell
ISSN:1463-5216
Publisher DOI:10.1111/j.1463-5224.2007.00550.x
PubMed ID:17760705
Permanent URL: http://doi.org/10.5167/uzh-5836

Download

[img]Filetype: PDF - Registered users only
Size: 1MB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations