Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-58397
Moransard, M; Dann, A; Staszewski, O; Fontana, A; Prinz, M; Suter, T (2011). NG2 expressed by macrophages and oligodendrocyte precursor cells is dispensable in experimental autoimmune encephalomyelitis. Brain: A Journal of Neurology, 134(Pt. 5):1315-1330.
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Increased expression of the chondroitin proteoglycan NG2 is a prominent feature in central nervous system injury with unknown cellular source and biological relevance. Here, we describe the first detailed analysis of experimental autoimmune encephalomyelitis in NG2 knockout mice and NG2 knockout bone marrow chimeras. We show that both macrophages and oligodendrocyte progenitor cells express and secrete NG2 in response to transforming growth factor-β. A subpopulation of macrophages expresses NG2 within leucocyte infiltrates in the central nervous system, but only oligodendrocyte progenitor cells contribute to NG2 accumulation. Notably, NG2 plays no role in experimental autoimmune encephalomyelitis initiation, progression or recuperation. In concurrence, the immune response is unaltered in NG2-deficient mice as are the extent of central nervous system damage and degree of remyelination.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Immunology|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||04 Mar 2012 10:08|
|Last Modified:||01 Dec 2013 16:03|
|Publisher:||Oxford University Press|
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