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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-58513

Irle, E; Lange, C; Ruhleder, M; Exner, C; Siemerkus, J; Weniger, G (2011). Hippocampal size in women but not men with schizophrenia relates to disorder duration. Psychiatry Research: Neuroimaging, 192(3):133-139.

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Abstract

Longitudinal studies have failed to find progressive hippocampal size reduction in schizophrenia. However, negative results may have been due to follow-up intervals at disease stages where no significant progressive brain changes occur. Furthermore, only male or mixed gender samples have been studied. Forty-six patients with schizophrenia (23 females) and 46 healthy controls (23 females) underwent three-dimensional structural magnetic resonance imaging of the hippocampus and a clinical investigation. Compared with controls, male but not female participants with schizophrenia displayed hippocampal size reduction. Hippocampal size of female but not male schizophrenia patients was related to disorder duration, indicating smaller hippocampal size in female patients with longer disorder duration. Female schizophrenia patients displayed normal hippocampal size at the onset of disorder, but similarly reduced hippocampal size as male schizophrenia patients after some years of illness had passed. Our results suggest preserved hippocampal size in women with schizophrenia during the first years of illness.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Clinical and Social Psychiatry Zurich West (former)
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:09 Mar 2012 13:58
Last Modified:04 Feb 2014 12:20
Publisher:Elsevier
ISSN:0925-4927
Publisher DOI:10.1016/j.pscychresns.2010.12.009
PubMed ID:21546218
Citations:Web of Science®. Times Cited: 1
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Scopus®. Citation Count: 2

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