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Reduced activity of the insulin/insulin-like growth factor signaling (IIS) pathway increases life-span in diverse organisms. We investigated the timing of the effect of reduced IIS on life-span and the role of a potential target tissue, the fat body. We overexpressed dFOXO, a downstream effector of IIS, in the adult Drosophila fat body, which increased life-span and reduced fecundity of females but had no effect on male life-span. The role of FOXO transcription factors and the adipose tissue are therefore evolutionarily conserved in the regulation of aging, and reduction of IIS in the adult is sufficient to mediate its effects on life-span and fecundity.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Zoology (former)|
|DDC:||570 Life sciences; biology|
590 Animals (Zoology)
|Date:||16 July 2004|
|Deposited On:||11 Feb 2008 12:16|
|Last Modified:||27 Nov 2013 22:16|
|Publisher:||American Association for the Advancement of Science (AAAS)|
|Citations:||Web of Science®. Times Cited: 246|
Scopus®. Citation Count: 270
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