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Intracellular protein trafficking


Hehl, A B (2011). Intracellular protein trafficking. In: Lujan, H D; Svärd, S. Giardia - A model Organism. Wien: Springer, 219-228.

Abstract

The secretory transport capacity of Giardia is perfectly adapted to its changing environment and is able to deploy essential protective surface coats as well as molecules, which act on host epithelia. The lumen-dwelling trophozoites take up nutrients by bulk endocytosis through peripheral vesicles or by receptor-mediated transport. Despite its versatility and fidelity, the giardial trafficking machinery appears to be the product of a general secondary reduction process that led to minimization of all components identified so far. Giardia is emerging as a model for the investigation of synthesis, transport, and assembly of highly effective biopolymers, a hallmark of all perorally transmitted protozoan and metazoan parasites. The cell biology of this simplified and highly derived organism allows unique insights into the function of minimal systems, which can be studied in an uncluttered cellular environment.

The secretory transport capacity of Giardia is perfectly adapted to its changing environment and is able to deploy essential protective surface coats as well as molecules, which act on host epithelia. The lumen-dwelling trophozoites take up nutrients by bulk endocytosis through peripheral vesicles or by receptor-mediated transport. Despite its versatility and fidelity, the giardial trafficking machinery appears to be the product of a general secondary reduction process that led to minimization of all components identified so far. Giardia is emerging as a model for the investigation of synthesis, transport, and assembly of highly effective biopolymers, a hallmark of all perorally transmitted protozoan and metazoan parasites. The cell biology of this simplified and highly derived organism allows unique insights into the function of minimal systems, which can be studied in an uncluttered cellular environment.

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Parasitology
04 Faculty of Medicine > Institute of Parasitology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
600 Technology
Language:English
Date:2011
Deposited On:07 Mar 2012 11:14
Last Modified:05 Apr 2016 15:35
Publisher:Springer
ISBN:978-3-7091-0197-1
Publisher DOI:10.1007/978-3-7091-0198-8_14
Related URLs:http://opac.nebis.ch/F/?local_base=NEBIS&CON_LNG=GER&func=find-b&find_code=SYS&request=006528730

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