Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-58953

Planzer, J; Kaufmann, C; Worwa, G; Gavier-Widén, D; Hofmann, M A; Chaignat, V; Thür, B (2011). In vivo and in vitro propagation and transmission of Toggenburg orbivirus. Research in Veterinary Science, 91(3):e163-e168.

[img]Published Version
PDF - Registered users only
View at publisher


The Toggenburg orbivirus (TOV), a recently discovered virus related to bluetongue virus (BTV), has been identified in goats in Switzerland, Italy and Germany. Isolation of TOV in vitro has not yet been achieved and the transmission mechanisms are still unknown. In the experimental infection of pregnant goats described here, TOV could not be detected in secretion/excretion samples or fetal blood. Material from the goat experiment was used as inoculum for propagating the virus in vitro. To enhance the infectivity of TOV several modified protocols, e.g. pretreatment of the virus with trypsin, polyethylene glycol-mediated infection and lipofection were applied. Isolation of TOV, attempts to infect Culicoides nubeculosus by feeding TOV-positive blood and intracerebral inoculation of newborn mice were unsuccessful. The results of these studies suggest that TOV requires specific but different factors than other BTVs for infection and replication outside of its natural caprine host.


9 citations in Web of Science®
15 citations in Scopus®
Google Scholar™



1 download since deposited on 07 Mar 2012
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Parasitology
04 Faculty of Medicine > Institute of Parasitology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
600 Technology
Deposited On:07 Mar 2012 11:21
Last Modified:05 Apr 2016 15:36
Publisher DOI:10.1016/j.rvsc.2011.03.007
PubMed ID:21458013

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page