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Erythropoietin in der onkologischen Therapie – was wissen wir über die Risiken?


Leo, C; Fink, D (2011). Erythropoietin in der onkologischen Therapie – was wissen wir über die Risiken? Praxis, 100(20):1239-46.

Abstract

Erythropoietin is a glycoprotein predominantly produced in the kidney. It is an essential regulator of erythropoiesis in the bone marrow. Although cancer-associated anemia is caused by multiple factors, recombinant erythropoietin (rhuEpo) was widely used to treat and prevent this condition. Several clinical studies showed that the use of rhuEpo results in an efficient reduction of red blood cell transfusions in cancer-associated anemia. However, over the past twenty years, Epo and its receptor EpoR were found to be expressed also outside the hematopoietic system and in malignant tumors. This led to a discussion concerning potential risks associated with the application of erythropoiesis-stimulating agents in oncology.

Erythropoietin is a glycoprotein predominantly produced in the kidney. It is an essential regulator of erythropoiesis in the bone marrow. Although cancer-associated anemia is caused by multiple factors, recombinant erythropoietin (rhuEpo) was widely used to treat and prevent this condition. Several clinical studies showed that the use of rhuEpo results in an efficient reduction of red blood cell transfusions in cancer-associated anemia. However, over the past twenty years, Epo and its receptor EpoR were found to be expressed also outside the hematopoietic system and in malignant tumors. This led to a discussion concerning potential risks associated with the application of erythropoiesis-stimulating agents in oncology.

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Additional indexing

Other titles:Erythropoietinin oncologic therapy - what so we know about the risks?
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gynecology
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2011
Deposited On:17 Feb 2012 12:24
Last Modified:05 Apr 2016 15:36
Publisher:Hans Huber
ISSN:1661-8157 (P) 1661-8165 (E)
Publisher DOI:10.1024/1661-8157/a000689
PubMed ID:21971618
Permanent URL: http://doi.org/10.5167/uzh-59067

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