Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-59155
Verschoor, A; Neuenhahn, M; Navarini, A A; Graef, P; Plaumann, A; Seidlmeier, A; Nieswandt, B; Massberg, S; Zinkernagel, R M; Hengartner, H; Busch, D H (2011). A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3. Nature Immunology, 12(12):1194-1201.
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The acquisition of pathogen-derived antigen by dendritic cells (DCs) is a key event in the generation of cytotoxic CD8(+) T cell responses. In mice, the intracellular bacterium Listeria monocytogenes is directed from the blood to splenic CD8α(+) DCs. We report that L. monocytogenes rapidly associated with platelets in the bloodstream in a manner dependent on GPIb and complement C3. Platelet association targeted a small but immunologically important portion of L. monocytogenes to splenic CD8α(+) DCs, diverting bacteria from swift clearance by other, less immunogenic phagocytes. Thus, an effective balance is established between maintaining sterility of the circulation and induction of antibacterial immunity by DCs. Other gram-positive bacteria also were rapidly tagged by platelets, revealing a broadly active shuttling mechanism for systemic bacteria.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic|
|DDC:||610 Medicine & health|
|Deposited On:||06 Mar 2012 18:45|
|Last Modified:||23 Nov 2012 13:37|
|Publisher:||Nature Publishing Group|
|Additional Information:||Comment in: Nat Rev Immunol. 2011 Dec;11(12):804. - Nat Immunol. 2011 Dec;12(12):1137-1138.|
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