Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-59155

Verschoor, A; Neuenhahn, M; Navarini, A A; Graef, P; Plaumann, A; Seidlmeier, A; Nieswandt, B; Massberg, S; Zinkernagel, R M; Hengartner, H; Busch, D H (2011). A platelet-mediated system for shuttling blood-borne bacteria to CD8α+ dendritic cells depends on glycoprotein GPIb and complement C3. Nature Immunology, 12(12):1194-1201.

[img]Published Version
PDF - Registered users only
View at publisher


The acquisition of pathogen-derived antigen by dendritic cells (DCs) is a key event in the generation of cytotoxic CD8(+) T cell responses. In mice, the intracellular bacterium Listeria monocytogenes is directed from the blood to splenic CD8α(+) DCs. We report that L. monocytogenes rapidly associated with platelets in the bloodstream in a manner dependent on GPIb and complement C3. Platelet association targeted a small but immunologically important portion of L. monocytogenes to splenic CD8α(+) DCs, diverting bacteria from swift clearance by other, less immunogenic phagocytes. Thus, an effective balance is established between maintaining sterility of the circulation and induction of antibacterial immunity by DCs. Other gram-positive bacteria also were rapidly tagged by platelets, revealing a broadly active shuttling mechanism for systemic bacteria.


46 citations in Web of Science®
49 citations in Scopus®
Google Scholar™



1 download since deposited on 06 Mar 2012
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Deposited On:06 Mar 2012 17:45
Last Modified:05 Apr 2016 15:37
Publisher:Nature Publishing Group
Additional Information:Comment in: Nat Rev Immunol. 2011 Dec;11(12):804. - Nat Immunol. 2011 Dec;12(12):1137-1138.
Publisher DOI:10.1038/ni.2140
PubMed ID:22037602

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page