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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-59219

Brough, R; Frankum, J R; Sims, D; Mackay, A; Mendes-Pereira, A M; Bajrami, I; Costa-Cabral, S; Rafiq, R; Ahmad, A S; Cerone, M A; Natrajan, R; Sharpe, R; Shiu, K K; Wetterskog, D; Dedes, K J; Lambros, M B; Rawjee, T; Linardopoulos, S; Reis-Filho, J S; Turner, N C; Lord, C J; Ashworth, A (2011). Functional viability profiles of breast cancer. Cancer Discovery, 1(3):260-273.

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Abstract

The design of targeted therapeutic strategies for cancer has been driven by the identification of tumor specific genetic changes. However, the large number of genetic alterations present in tumor cells means that it is difficult to discriminate between genes that are critical for maintenance of the disease state from those that are merely coincidental. Even when critical genes can be identified, directly targeting these is often challenging, meaning that alternative strategies such as exploiting synthetic lethality may be beneficial. To address these issues, we have carried out a functional genetic screen in over 30 commonly used models of breast cancer to identify genes that are critical for the growth of specific breast cancer subtypes. In particular, we describe potential new therapeutic targets for PTEN mutated cancers and for ER+ve breast cancers. We also show that large-scale functional profiling allows the classification of breast cancers into subgroups distinct from established subtypes.

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49 citations in Web of Science®
53 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gynecology
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:16 Feb 2012 15:50
Last Modified:06 Dec 2013 17:59
Publisher:American Association for Cancer Research
ISSN:2159-8274 (P) 2159-8290 (E)
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1158/2159-8290.CD-11-0107
PubMed ID:21984977

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