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Das epitheliale Ovarialkarzinom – ein Paradigmenwandel


Heinzelmann-Schwarz, V (2011). Das epitheliale Ovarialkarzinom – ein Paradigmenwandel. Therapeutische Umschau, 68(10):565-572.

Abstract

Epithelial ovarian cancer has the highest mortality rate within gynecological cancers as early symptoms are vague and unspecific and two-thirds of patients are presenting with advanced stage disease. Due to the innovative findings of proteo-genomic studies during the last decade a change in paradigm has occurred. Ovarian cancer, which so far was assumed to be one disease deriving from a single layer of ovarian surface epithelial cells, has now become known to be heterogeneous and genetically distinct from each other, possibly even deriving from different parts of the female genital system. Our continuously increasing knowledge has made us aware that diagnosis and therapy has to target the molecular pathway more than the organ of origin. This will impact on ovarian cancer and will make it more and more controllable during the next ten years.

Epithelial ovarian cancer has the highest mortality rate within gynecological cancers as early symptoms are vague and unspecific and two-thirds of patients are presenting with advanced stage disease. Due to the innovative findings of proteo-genomic studies during the last decade a change in paradigm has occurred. Ovarian cancer, which so far was assumed to be one disease deriving from a single layer of ovarian surface epithelial cells, has now become known to be heterogeneous and genetically distinct from each other, possibly even deriving from different parts of the female genital system. Our continuously increasing knowledge has made us aware that diagnosis and therapy has to target the molecular pathway more than the organ of origin. This will impact on ovarian cancer and will make it more and more controllable during the next ten years.

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Additional indexing

Other titles:Epithelial ovarian cancer - a change of paradigm
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gynecology
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2011
Deposited On:17 Feb 2012 09:50
Last Modified:05 Apr 2016 15:37
Publisher:Verlag Hans Huber
ISSN:0040-5930 (P) 1664-2864 (E)
Publisher DOI:10.1024/0040-5930/a000215
PubMed ID:21968896
Permanent URL: http://doi.org/10.5167/uzh-59252

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