Bischoff-Ferrari, H A (2012). Relevance of vitamin D in muscle health. Reviews in Endocrine & Metabolic Disorders, 13(1):71-77.
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This review will summarize the impact of vitamin D deficiency on muscle health. Mechanistic evidence regarding the presence of the specific vitamin D receptor in muscle tissue and muscle biopsy abnormalities observed with deficiency will be reviewed, as well as molecular and non-molecular effects of vitamin D in muscle tissue. At the clinical level, the evidence from randomized controlled trials of vitamin D supplementation on functional improvement and fall reduction will be summarized. Further, the manuscript will discuss whether vitamin D effects on fall prevention modulate in part its benefit on fracture prevention and why fall prevention is essential in fracture prevention at higher age. Finally, trial and epidemiological data will be reviewed to assess desirable serum 25-hydroxyvitamin D levels for optimal muscle health.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine|
04 Faculty of Medicine > Center on Aging and Mobility
|DDC:||360 Social problems & social services|
610 Medicine & health
300 Social sciences, sociology & anthropology
|Deposited On:||26 Feb 2012 16:04|
|Last Modified:||28 Nov 2013 00:13|
|Citations:||Web of Science®. Times Cited: 16|
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