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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila.


Stocker, H; Radimerski, T; Schindelholz, B; Wittwer, F; Belawat, P; Daram, P; Breuer, S; Thomas, G; Hafen, E (2003). Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nature Cell Biology, 5(6):559-565.

Abstract

Understanding the mechanisms through which multicellular organisms regulate cell, organ and body growth is of relevance to developmental biology and to research on growth-related diseases such as cancer. Here we describe a new effector in growth control, the small GTPase Rheb (Ras homologue enriched in brain). Mutations in the Drosophila melanogaster Rheb gene were isolated as growth-inhibitors, whereas overexpression of Rheb promoted cell growth. Our genetic and biochemical analyses suggest that Rheb functions downstream of the tumour suppressors Tsc1 (tuberous sclerosis 1)-Tsc2 in the TOR (target of rapamycin) signalling pathway to control growth, and that a major effector of Rheb function is ribosomal S6 kinase (S6K).

Understanding the mechanisms through which multicellular organisms regulate cell, organ and body growth is of relevance to developmental biology and to research on growth-related diseases such as cancer. Here we describe a new effector in growth control, the small GTPase Rheb (Ras homologue enriched in brain). Mutations in the Drosophila melanogaster Rheb gene were isolated as growth-inhibitors, whereas overexpression of Rheb promoted cell growth. Our genetic and biochemical analyses suggest that Rheb functions downstream of the tumour suppressors Tsc1 (tuberous sclerosis 1)-Tsc2 in the TOR (target of rapamycin) signalling pathway to control growth, and that a major effector of Rheb function is ribosomal S6 kinase (S6K).

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325 citations in Web of Science®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Zoology (former)
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:1 June 2003
Deposited On:11 Feb 2008 12:16
Last Modified:05 Apr 2016 12:14
Publisher:Nature Publishing Group
ISSN:1465-7392
Publisher DOI:10.1038/ncb995
PubMed ID:12766775
Permanent URL: http://doi.org/10.5167/uzh-594

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