Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-59404
Grau, Thomas; Selchow, Petra; Tigges, Marcel; Burri, Reto; Gitzinger, Marc; Böttger, Erik C; Fussenegger, Martin; Sander, Peter (2012). Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy, 56(2):1142-1145.
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Abstract
Ethionamide (ETH) is a second-line drug for the treatment of tuberculosis. As a prodrug, ETH has to be activated by EthA. ethA is controlled by its repressor EthR. 2-Phenylethyl-butyrate (2-PEB) inhibits EthR binding, enhances expression of EthA, and thereby enhances the growth-inhibitory effects of ethionamide, isoxyl, and thiacetazone in Mycobacterium tuberculosis strains with resistance to ETH due to inhA promoter mutations but not ethA mutations.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Institute of Medical Microbiology |
| DDC: | 570 Life sciences; biology 610 Medicine & health |
| Language: | English |
| Date: | 2012 |
| Deposited On: | 03 Apr 2012 10:57 |
| Last Modified: | 26 Nov 2012 05:21 |
| Publisher: | American Society for Microbiology (ASM) |
| ISSN: | 0066-4804 |
| Publisher DOI: | 10.1128/AAC.05649-11 |
| PubMed ID: | 22106218 |
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