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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-59406

Lucke, Katja; Hombach, Michael; Friedel, Ute; Ritter, Claudia; Böttger, Erik C (2012). Automated quantitative drug susceptibility testing of non-tuberculous mycobacteria using MGIT 960/EpiCenter TB eXiST. Journal of Antimicrobial Chemotherapy, 67(1):154-158.

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Abstract

OBJECTIVES:

To assess the predictive value of in vitro drug susceptibility testing (DST) in slow-growing non-tuberculous mycobacteria (NTM), knowledge on quantitative levels of drug susceptibility should be available. The aim of this study was to investigate the suitability of the MGIT 960/TB eXiST system for quantitative DST of NTM.
METHODS:

We have assessed quantitative levels of drug susceptibility for clinical isolates of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium kansasii by comparing radiometric Bactec 460TB-based DST with non-radiometric DST using MGIT 960/TB eXiST.
RESULTS:

MGIT 960/TB eXiST gives results comparable to those of Bactec 460TB.
CONCLUSIONS:

The MGIT 960/TB eXiST appears suitable for quantitative DST of NTM.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2012
Deposited On:03 Apr 2012 09:01
Last Modified:20 Jan 2014 05:10
Publisher:Oxford University Press
ISSN:0305-7453
Publisher DOI:10.1093/jac/dkr399
PubMed ID:21965431
Citations:Web of Science®. Times Cited: 3
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Scopus®. Citation Count: 4

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