Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-59594
Noffke, A L; Bongartz, M; Wätjen, W; Böhler, P; Spingler, B; Kunz, P C (2011). Synthesis, X-ray crystal structure and cytotoxicity of a new tetranuclear ruthenium arene complex. Journal of Organometallic Chemistry, 696(5):1096-1101.
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The tetranuclear ruthenium arene compound [(cym)4Ru4(2)Cl6]Cl2 (3) (cym = η6-p-cymene, 2 = 1,2-bis(di-N-methylimidazol-2-ylphosphino)ethane) was prepared and characterised by one- and two-dimensional NMR techniques. Its cytotoxicity against four different cell lines was determined and, with an approximate IC50 of >100 μM 3 can be regarded as non-toxic. Its partition coefficient in n-octanol/water (log D7.4) was also determined. The structures of complex 3 as well as of the related compound [(cym)2Ru2(4)Cl2]Cl2 (5) (4 = 1,2-bis(di-N-methylimidazol-2-ylphosphino)ethane dioxide) were determined by single crystal structure analysis. Upon oxidation in protic solvents, ligand 2 shows P–C bond cleavage reactions to yield P,P′-bis(N-methylimidazol-2-yl)ethylene diphosphinic acid (6).
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Department of Chemistry|
|Date:||1 March 2011|
|Deposited On:||09 Mar 2012 15:44|
|Last Modified:||30 Nov 2013 02:32|
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