Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-59602
Wetzel, C; Kunz, P C; Kassack, M U; Hamacher, A; Böhler, P; Watjen, W; Ott, I; Rubbiani, R; Spingler, B (2011). Gold(i) complexes of water-soluble diphos-type ligands: Synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition. Dalton Transactions, 40(36):9212-9220.
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Gold(I) complexes of imidazole and thiazole-based diphos type ligands were prepared and their potential as chemotherapeutics investigated. Depending on the ligands employed and the reaction conditions complexes [L(AuCl)2] and [L2Au]X (X = Cl, PF6) are obtained. The ligands used are diphosphanes with azoyl substituents R2P(CH2)2PR2 as well as the novel ligands RPhP(CH2)2PRPh and R2P(CH2)3PR2 . The cytotoxic activity of the complexes was assessed against three human cancer cell lines and a rat hepatoma cell line and correlated to the lipophilicity of the compounds. The tetrahedral gold complexes [(3)2Au]PF6 and [(5)2Au]PF6 with intermediate lipophilicity (logD7.4 = 0.21 and 0.25) showed significant cytotoxic activity in different cell lines. Both compounds induce apoptosis and inhibit the enzymes thioredoxin reductase and glutathione reductase.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Department of Chemistry|
|Deposited On:||15 Mar 2012 07:35|
|Last Modified:||30 Nov 2013 07:55|
|Publisher:||Royal Society of Chemistry|
|Free access at:||Publisher DOI. An embargo period may apply.|
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