Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-5986
Brown, S A; Kunz, D; Dumas, A; Westermark, P O; Vanselow, K; Tilmann-Wahnschaffe, A; Herzel, H; Kramer, A (2008). Molecular insights into human daily behavior. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 105(5):1602-1607.
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Human beings exhibit wide variation in their timing of daily behavior. We and others have suggested previously that such differences might arise because of alterations in the period length of the endogenous human circadian oscillator. Using dermal fibroblast cells from skin biopsies of 28 subjects of early and late chronotype (11 "larks" and 17 "owls"), we have studied the circadian period lengths of these two groups, as well as their ability to phase-shift and entrain to environmental and chemical signals. We find not only period length differences between the two classes, but also significant changes in the amplitude and phase-shifting properties of the circadian oscillator among individuals with identical "normal" period lengths. Mathematical modeling shows that these alterations could also account for the extreme behavioral phenotypes of these subjects. We conclude that human chronotype may be influenced not only by the period length of the circadian oscillator, but also by cellular components that affect its amplitude and phase. In many instances, these changes can be studied at the molecular level in primary dermal cells.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Pharmacology and Toxicology|
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Date:||05 February 2008|
|Deposited On:||24 Nov 2008 09:32|
|Last Modified:||27 Nov 2013 18:13|
|Publisher:||National Academy of Sciences|
|Additional Information:||Copyright: National Academy of Sciences USA|
|Citations:||Web of Science®. Times cited: 79|
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