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Bioinorganic Chemistry Special Feature: Canonical and unconventional pairing schemes between bis(nucleobase) complexes of trans-a2PtII: Artificial nucleobase quartets and C-H...N bonds


Freisinger, E; Rother, I B; Lüth, M S; Lippert, B (2003). Bioinorganic Chemistry Special Feature: Canonical and unconventional pairing schemes between bis(nucleobase) complexes of trans-a2PtII: Artificial nucleobase quartets and C-H...N bonds. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 100(7):3748-3753.

Abstract

If two nucleobases are crosslinked by trans-a2PtII, self-association via H bonding may take place either through individual bases or jointly through both bases. Due to the blockage of an acceptor site by the metal, the number of feasible pairing patterns can be reduced, and the preferred ones altered. If the metalated base pair as a whole undergoes association, base quartets can form. Various scenarios resulting from the application of guanine, hypoxanthine, and cytosine model nucleobases are discussed. Unconventional C—H…N hydrogen bonding has been observed in several instances.

If two nucleobases are crosslinked by trans-a2PtII, self-association via H bonding may take place either through individual bases or jointly through both bases. Due to the blockage of an acceptor site by the metal, the number of feasible pairing patterns can be reduced, and the preferred ones altered. If the metalated base pair as a whole undergoes association, base quartets can form. Various scenarios resulting from the application of guanine, hypoxanthine, and cytosine model nucleobases are discussed. Unconventional C—H…N hydrogen bonding has been observed in several instances.

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31 citations in Web of Science®
28 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2003
Deposited On:27 Jun 2012 11:36
Last Modified:05 Apr 2016 15:40
Publisher:National Academy of Sciences
ISSN:0027-8424
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1073/pnas.0436700100

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