Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Riera, X; Moreno, V; Freisinger, E; Lippert, B (2002). Pd(II) and Pt(II) (R,S)-3-aminopyrrolidine complexes. Reactions with 9-ethylguanine and study of their antiproliferative activity. Inorganica Chimica Acta, 339:253-264.

Full text not available from this repository.

Abstract

Three new metal complexes {M=Pd(II) or Pt(II)} containing the ligand 3-aminopyrrolidine were prepared. The compounds were characterised by IRFT, and 1H, 13C and 195Pt NMR spectroscopies. Crystal structures of the palladium complexes of formulae cis-[PdCl2(pyrr)] and trans-[Pd(pyrr)2](ClO4)2 were determined by X-ray diffraction. The ligand binds to the metal ions in a bidentate fashion through the two nitrogen atoms in all prepared complexes. The reactivity of the complexes with the model nucleobase 9-ethylguanine was studied. The 1H NMR study at variable pH* allowed to calculate the pKa value for the platinum compound. The unexpected behaviour of the analogous palladium complex suggests a hydrolysis process and the formation of hydroxy-species. The capacity of the compounds for the modification of the secondary and tertiary structure of DNA was evaluated by means of circular dichroism and electrophoretic mobility. The platinum compound proved active in the modification of both these structures. Finally, the complexes were tested for antiproliferative activity against three different human tumour cell lines. The results suggest that the platinum complex of formula cis-[PtCl2(pyrr)] has significant antiproliferative activity, but that is less active than cisplatin.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Inorganic Chemistry
DDC:540 Chemistry
Language:English
Date:2002
Deposited On:27 Jun 2012 13:27
Last Modified:27 Nov 2013 20:28
Publisher:Elsevier
ISSN:0020-1693
Publisher DOI:10.1016/S0020-1693(02)00957-X
Citations:Web of Science®. Times Cited: 8
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page