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Diplatinum(III) complexes with bridging 1-methylcytosinate ligands and variable axial ligands, including guanine nucleobases


Kampf, Gunnar; Willermann, Michael; Freisinger, Eva; Lippert, Bernhard (2002). Diplatinum(III) complexes with bridging 1-methylcytosinate ligands and variable axial ligands, including guanine nucleobases. Inorganica Chimica Acta, 330(1):179-188.

Abstract

A series of diplatinum(III) complexes derived from cis-(NH3)2PtII and the model nucleobase 1-methylcytosine (1-MeC) has been prepared and X-ray structurally characterized, all of which contain two anionic base ligands (1-MeC−) in a head–tail (ht) arrangement: ht-cis-[(ONO2)(NH3)2Pt(1-MeC−-N3,N4)2Pt(NH3)2(ONO2)](NO3)2·HNO3·3H2O (2b), ht-cis-[(NO2) (NH3)2 Pt(1-MeC−-N3,N4)2Pt(NH3)2(OH2)](ClO4)3·3.5H2O (3), ht-cis-[(OH2)(NH3)2Pt(1-MeC−-N3,N4)2Pt(NH3)2(OH2)](ClO4)4·H2O (4b), and ht-cis-[(9-EtGH-N7)(NH3)2Pt(1-MeC−-N3,N4)2Pt (NH3)2(9-EtGH-N7)](NO3)4·9H2O (7b) (9-EtGH=9-ethylguanine). Several other compounds, differing in the nature of the axial ligands, have been isolated and or observed in solution by 1H and 195Pt NMR spectroscopy. The chemistry of these diplatinum(III) compounds is dominated by facile substitution reactions of the axial ligands. Of particular interest in this context is the ready reaction of 2b or 3 with guanine nucleobases. Since similar compounds are not obtained with any of the other common nucleobases, 2b and 3 can be considered guanine-specific chemical probes.

Abstract

A series of diplatinum(III) complexes derived from cis-(NH3)2PtII and the model nucleobase 1-methylcytosine (1-MeC) has been prepared and X-ray structurally characterized, all of which contain two anionic base ligands (1-MeC−) in a head–tail (ht) arrangement: ht-cis-[(ONO2)(NH3)2Pt(1-MeC−-N3,N4)2Pt(NH3)2(ONO2)](NO3)2·HNO3·3H2O (2b), ht-cis-[(NO2) (NH3)2 Pt(1-MeC−-N3,N4)2Pt(NH3)2(OH2)](ClO4)3·3.5H2O (3), ht-cis-[(OH2)(NH3)2Pt(1-MeC−-N3,N4)2Pt(NH3)2(OH2)](ClO4)4·H2O (4b), and ht-cis-[(9-EtGH-N7)(NH3)2Pt(1-MeC−-N3,N4)2Pt (NH3)2(9-EtGH-N7)](NO3)4·9H2O (7b) (9-EtGH=9-ethylguanine). Several other compounds, differing in the nature of the axial ligands, have been isolated and or observed in solution by 1H and 195Pt NMR spectroscopy. The chemistry of these diplatinum(III) compounds is dominated by facile substitution reactions of the axial ligands. Of particular interest in this context is the ready reaction of 2b or 3 with guanine nucleobases. Since similar compounds are not obtained with any of the other common nucleobases, 2b and 3 can be considered guanine-specific chemical probes.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2002
Deposited On:27 Jun 2012 11:19
Last Modified:05 Apr 2016 15:40
Publisher:Elsevier
ISSN:0020-1693
Publisher DOI:https://doi.org/10.1016/S0020-1693(01)00741-1

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