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Acne Vulgaris


Läuchli, S (2011). Acne Vulgaris. In: Allemann, B; Goldberg, D J. Basics in Dermatological Laser Applications. Basel, CH: Karger, 140-146.

Abstract

Acne Vulgaris is one of the most common dermatological diseases, and caused by a combination of pathogenetic factors including follicular hyperkeratosis, seborrhea, colonization with Propionibacterium acnes and inflammatory phenomena. Various medical treatments address these causative factors, but they are not always well tolerated. In the last decades, there has been increased interest in laser and light-based treatments. These optical devices mainly target Propionibacterium acnes by activating porphyrins produced by the bacterium, wheras some treatments directly lead to the destruction of sebaceous glands. Photodynamic therapy can enhance these effects throught the prior application of a photosensitizing agent. Many laser and light-based treatments have shown excellent clinical results in the reduction of inflammatory acne lesions and improved acne severity. Although relapses are frequent, results can be improved by combination therapy with conventional medical treatments. Data of randomized controlled studies or studies with a split-face design are contradictory and difficult to compare. Furthermore, the cost of the treatments is often a limiting factor. In summary, some optical devices are an important additional tool in the treatment of patients with mainly inflammatory acne where conventional treatments are not well tolerated.

Abstract

Acne Vulgaris is one of the most common dermatological diseases, and caused by a combination of pathogenetic factors including follicular hyperkeratosis, seborrhea, colonization with Propionibacterium acnes and inflammatory phenomena. Various medical treatments address these causative factors, but they are not always well tolerated. In the last decades, there has been increased interest in laser and light-based treatments. These optical devices mainly target Propionibacterium acnes by activating porphyrins produced by the bacterium, wheras some treatments directly lead to the destruction of sebaceous glands. Photodynamic therapy can enhance these effects throught the prior application of a photosensitizing agent. Many laser and light-based treatments have shown excellent clinical results in the reduction of inflammatory acne lesions and improved acne severity. Although relapses are frequent, results can be improved by combination therapy with conventional medical treatments. Data of randomized controlled studies or studies with a split-face design are contradictory and difficult to compare. Furthermore, the cost of the treatments is often a limiting factor. In summary, some optical devices are an important additional tool in the treatment of patients with mainly inflammatory acne where conventional treatments are not well tolerated.

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Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:18 Mar 2012 09:44
Last Modified:05 Apr 2016 15:40
Publisher:Karger
Series Name:Current Problems in Dermatology
Number:42
ISSN:1421-5721
ISBN:978-3-8055-9788-3 (P) 978-3-8055-9789-0 (E)
Publisher DOI:https://doi.org/10.1159/000328282
Related URLs:http://content.karger.com/ProdukteDB/produkte.asp?isbn=978-3-8055-9788-3 (Publisher)
http://opac.nebis.ch/F/?local_base=NEBIS&CON_LNG=GER&func=find-b&find_code=SYS&request=006594337

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