Zipser, M C; Dummer, R (2011). Epidemiology of histocytoses. In: Dummer, R; Pittelkow, M R; Iwatsuki, K; Green, A; Elwan, N M. Skin cancer - a world-wide perspective. Heidelberg, DE, 33-34. ISBN 978-3-642-05071-8 (P) 978-3-642-05072-5 (E).
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Langerhans cell histiocytisis (LCH) is the most common of the histiocytic disorders . It represents a spectrum of several clinical entities chracterized by a disorder of antigenpresenting dendritic cells of the immune system. Its epidemiology is poorly understood and based mainly on a few international and regional studies of defined populations . The overall incidence rate varies from 2.6 to 8.9 children per million per year [1, 19, 34, 36]. Children of any age can be affected, however the peak age of presentation, in children, is between the ages of one and three . LCH is also diagnosed in adults  but only a few reports are available describing LCH patients with onset during adulthood . Some studies reveal a greater prevalence of LCH among male children . On the other hand, in adults, a preponderance of females is documented with onset as late as the ninth decade of life . Dissemitaned LCH is described to present most frequently in the first year of life . Congenital self-healing LCH is an uncommon form of LCH, which is usually present at birth or in the neonatal period .
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|Item Type:||Book Section, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic|
|DDC:||610 Medicine & health|
|Deposited On:||11 Mar 2012 19:04|
|Last Modified:||04 Apr 2012 14:24|
|ISBN:||978-3-642-05071-8 (P) 978-3-642-05072-5 (E)|
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