Zipser, M C; Dummer, R (2011). Pathogenesis of histiocytoses. In: Dummer, R; Pittelkow, M; Iwatsuki, K; Green, A; Elwan, N M. Skin cancer - a world-wide perspective. Heidelberg, DE: Springer, 73-74.
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Langerhans cell histiocytosis (LCH) is a disease of unknown etiology showing clonal proliferation of Langerhans-like cells or their precursors [1, 16]. Pathologic LCH cells appear to be in an immature state of activation and/or differentiation . They accumulate in peripheral tissue and express inflammatory cytokines resulting in their own recruitment and retention . Moreover, activated CD40 ligand expressing T helper cells are found to be the predominant source of cytokines and growth factors in LCH lesions . The “cytokine storm” seems to be further enhanced by the interaction of CD40 expressing LCH cells and CD40 ligand expressing T-cells . High levels of granulocyte-macrophage colony-stimulating factor, tumor-necrosis factor alpha, interleukin-3, and other cytokines are potential chemoattractants for recruiting eosinophils, neutrophils, marcrophages, and CD34+ Langerhans cell precursors into the LCH lesion [3, 7]. These cytokines are known to contribute directly to the development of fibrosis, necrosis, and osteolysis . They are also supposed to play a role in the presence of several other myeloid cell types; the multinucleated giant cell (MGC), amongst others, was found in LCH lesions . MGCs are believed to play a major role in tissue destruction, as they are express osteoclast markers . Remarkably, though various inflammatory cytokines are present in LCH lesions, LCH cells remain immature and do not maturate . Lesional microenvironment seems to play a role in the maintenance of the phenotype of LCH cells .
|Item Type:||Book Section, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic|
|Dewey Decimal Classification:||610 Medicine & health|
|Deposited On:||11 Mar 2012 19:07|
|Last Modified:||07 Apr 2015 07:30|
|ISBN:||978-3-642-05071-8 (P) 978-3-642-05072-5 (E)|
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