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Identification of brain regions that differentially respond to pain intensity may improve our understanding of trigeminally mediated nociception. This report analyzed cortical responses to painless and painful electrical stimulation of a right human maxillary canine tooth. Functional magnetic resonance images were obtained during the application of five graded stimulus strengths, from below, at, and above the individually determined pain thresholds. Study participants reported each stimulus on a visual rating scale with respect to evoked sensation. Based on hemodynamic responses of all pooled stimuli, a cerebral network was identified that largely corresponds to the known lateral and medial nociceptive system. Further analysis of the five graded stimulus strengths revealed positive linear correlations for the anterior insula bilaterally, the contralateral (left) anterior mid-cingulate, as well as contralateral (left) pregenual cingulate cortices. Cerebral toothache intensity coding on a group level can thus be attributed to specific subregions within the cortical pain network.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Center for Dental Medicine > Clinic for Fixed and Removable Prosthodontics|
06 Faculty of Arts > Institute of Psychology
04 Faculty of Medicine > Center for Dental Medicine > Clinic for Masticatory Disorders and Complete Dentures, Geriatric and Special Care Dentistry
04 Faculty of Medicine > Institute of Biomedical Engineering
610 Medicine & health
|Uncontrolled Keywords:||facial pain/physiopathology, toothache/physiopathology, physical stimulation, pain/physiopathology, physical stimulation, func- tional MRI.|
|Deposited On:||10 Oct 2012 11:14|
|Last Modified:||28 Nov 2013 02:58|
|Citations:||Web of Science®. Times Cited: 5|
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