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Metal-containing peptide nucleic acid conjugates


Gasser, Gilles; Sosniak, Anna M; Metzler-Nolte, Nils (2011). Metal-containing peptide nucleic acid conjugates. Dalton Transactions, 40(27):7061-7076.

Abstract

Peptide Nucleic Acids (PNAs) are non-natural DNA/RNA analogues with favourable physico-chemical properties and promising applications. Discovered nearly 20 years ago, PNAs have recently re-gained quite a lot of attention. In this Perspective article, we discuss the latest advances on the preparation and utilisation of PNA monomers and oligomers containing metal complexes. These metal- conjugates have found applications in various research fields such as in the sequence-specific detection of nucleic acids, in the hydrolysis of nucleic acids and peptides, as radioactive probes or as modulators of PNA˙DNA hybrid stability, and last but not least as probes for molecular and cell biology.

Peptide Nucleic Acids (PNAs) are non-natural DNA/RNA analogues with favourable physico-chemical properties and promising applications. Discovered nearly 20 years ago, PNAs have recently re-gained quite a lot of attention. In this Perspective article, we discuss the latest advances on the preparation and utilisation of PNA monomers and oligomers containing metal complexes. These metal- conjugates have found applications in various research fields such as in the sequence-specific detection of nucleic acids, in the hydrolysis of nucleic acids and peptides, as radioactive probes or as modulators of PNA˙DNA hybrid stability, and last but not least as probes for molecular and cell biology.

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38 citations in Web of Science®
40 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2011
Deposited On:15 Mar 2012 14:21
Last Modified:05 Apr 2016 15:41
Publisher:Royal Society of Chemistry
ISSN:1477-9226
Additional Information:Persons who receive the PDF must not make it further available or distribute it.
Publisher DOI:https://doi.org/10.1039/C0DT01706J
PubMed ID:21541385
Permanent URL: https://doi.org/10.5167/uzh-60259

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