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Mechano-chemical simulation of solid tumor dynamics for therapy outcome predictions


Hirsch, S; Szczerba, D; Lloyd, B; Bajka, M; Kuster, N; Székely, G (2011). Mechano-chemical simulation of solid tumor dynamics for therapy outcome predictions. International Journal for Multiscale Computational Engineering, 9(2):231-241.

Abstract

Experimental investigations of tumors often result in data reflecting very complex underlying mechanisms. Computer
models of such phenomena enable their analysis and may lead to novel and more efficient therapy strategies. We present
a generalized finite-element mechano-chemical model of a solid tumor and assess its suitability for predicting therapy outcome. The model includes hosting tissue, tumor cells (vital and necrotic), nutrient (oxygen), blood vessels, and a growth inhibitor. At a certain time instant of the tumor development virtual therapies are performed and their outcomes are presented. The model parameters are obtained either directly from the available literature or estimated using multiscale modeling. First results indicate the usefulness of multi-physics tumor models for predicting therapy response. In the proposed model a regression of a manifest tumor after therapy may be observed.

Experimental investigations of tumors often result in data reflecting very complex underlying mechanisms. Computer
models of such phenomena enable their analysis and may lead to novel and more efficient therapy strategies. We present
a generalized finite-element mechano-chemical model of a solid tumor and assess its suitability for predicting therapy outcome. The model includes hosting tissue, tumor cells (vital and necrotic), nutrient (oxygen), blood vessels, and a growth inhibitor. At a certain time instant of the tumor development virtual therapies are performed and their outcomes are presented. The model parameters are obtained either directly from the available literature or estimated using multiscale modeling. First results indicate the usefulness of multi-physics tumor models for predicting therapy response. In the proposed model a regression of a manifest tumor after therapy may be observed.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gynecology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:26 Feb 2012 20:18
Last Modified:05 Apr 2016 15:41
Publisher:Begell House Inc.
ISSN:1543-1649
Publisher DOI:10.1615/IntJMultCompEng.v9.i2.70
Official URL:http://www.begellhouse.com/journals/61fd1b191cf7e96f,510397234a1cbb30,5f7815e343cde965.html
Permanent URL: http://doi.org/10.5167/uzh-60320

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