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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-60349

Hofer, K E; Trachsel, C; Rauber-Lüthy, C; Kupferschmidt, H; Kullak-Ublick, G A; Ceschi, A (2011). Moderate toxic effects following acute zonisamide overdose. Epilepsy & Behavior, 21(1):91-93.

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Abstract

Zonisamide is an antiepileptic drug that acts on voltage-sensitive sodium and calcium channels, with a modulatory effect on GABA-mediated neuronal inhibition and an inhibitory effect on carbonic anhydrase. It is used mainly for the treatment of partial seizures, and is generally well tolerated at therapeutic doses. The most common reported adverse effects are somnolence, anorexia, dizziness, and headache. There are limited data on zonisamide overdose in the literature, and no case of zonisamide mono-intoxication has been published to date. We describe the first case of zonisamide mono-intoxication in a 25-year-old woman who ingested 12.6 g of this substance with suicidal intent. Despite a plasma zonisamide concentration of 182 mg/L on admission, the patient exhibited a benign clinical course with vomiting and central nervous system depression, requiring brief intubation. Somnolence persisted for 50 hours, and normal-anion-gap metabolic acidosis and polyuria for several days. Complete recovery may be expected with supportive care, even after ingestion of large zonisamide overdoses.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
DDC:610 Medicine & health
Language:English
Date:2011
Deposited On:27 Feb 2012 21:29
Last Modified:29 Nov 2013 23:56
Publisher:Elsevier
ISSN:1525-5050
Publisher DOI:10.1016/j.yebeh.2011.02.023
PubMed ID:21463969
Citations:Web of Science®
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