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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-60374

Thipyapong, K; Uehara, T; Tooyama, Y; Braband, H; Alberto, R (2011). Insights into technetium amidoxime complex: oxo technetium(V) complex of n-substituted benzamidoxime as new basic structure for molecular imaging. Inorganic Chemistry, 50(3):992-998.

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Abstract

In search of benzamidoxime (BHam) derivatives that provide a single 99mTc-labeled compound of high in vivo stability, we synthesized three N-alkyl compounds of benzamidoxime (BHam) ligand. They provided a single 99mTc-labeled compound by ligand exchange reaction of 99mTc-glucoheptonate in high radiochemical yields (over 95% at MBHam concentration of 1 × 10−5 M). 99mTc-N-methyl benzamidoxime (99mTc-MBHam) showed higher stability than the parental 99mTc-BHam. The complex of this compound with 99gTcO3+ ion was prepared, isolated, and characterized by FT-IR and NMR spectra as well as X-ray diffraction. 99gTc-MBHam crystallized in an orthorhombic space group Pna21 with a = 13.4823(5), b = 15.5410(7), c = 7.7907(3) Å, V = 1632.39(11) Å3, and Z = 4. The 99gTc complex possessed square base pyramid coordination geometry. The equatorial plane was formed by two-amine nitrogen and two-oxime oxygen atoms in trans position, while the oxo core of the technetium(V) occupied the apical position. The 99gTc-MBHam proved to be identical with the 99mTc-MBHam prepared at the no-carrier-added level by comparison of their HPLC profiles.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
DDC:540 Chemistry
Language:English
Date:2011
Deposited On:15 Mar 2012 07:50
Last Modified:28 Nov 2013 07:28
Publisher:American Chemical Society
ISSN:0020-1669
Publisher DOI:10.1021/ic101714q
Citations:Web of Science®. Times Cited: 5
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Scopus®. Citation Count: 6

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