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What’s black and white about the grey matter?


Douglas, R J; Martin, K A C (2011). What’s black and white about the grey matter? Neuroinformatics, 9(2-3):167-179.

Abstract

In 1873 Camillo Golgi discovered his eponymous stain, which he called la reazione nera. By adding to it the concepts of the Neuron Doctrine and the Law of Dynamic Polarisation, Santiago Ramon y Cajal was able to link the individual Golgi-stained neurons he saw down his microscope into circuits. This was revolutionary and we have all followed Cajal's winning strategy for over a century. We are now on the verge of a new revolution, which offers the prize of a far more comprehensive description of neural circuits and their operation. The hope is that we will exploit the power of computer vision algorithms and modern molecular biological techniques to acquire rapidly reconstructions of single neurons and synaptic circuits, and to control the function of selected types of neurons. Only one item is now conspicuous by its absence: the 21st century equivalent of the concepts of the Neuron Doctrine and the Law of Dynamic Polarisation. Without their equivalent we will inevitably struggle to make sense of our 21st century observations within the 19th and 20th century conceptual framework we have inherited.

In 1873 Camillo Golgi discovered his eponymous stain, which he called la reazione nera. By adding to it the concepts of the Neuron Doctrine and the Law of Dynamic Polarisation, Santiago Ramon y Cajal was able to link the individual Golgi-stained neurons he saw down his microscope into circuits. This was revolutionary and we have all followed Cajal's winning strategy for over a century. We are now on the verge of a new revolution, which offers the prize of a far more comprehensive description of neural circuits and their operation. The hope is that we will exploit the power of computer vision algorithms and modern molecular biological techniques to acquire rapidly reconstructions of single neurons and synaptic circuits, and to control the function of selected types of neurons. Only one item is now conspicuous by its absence: the 21st century equivalent of the concepts of the Neuron Doctrine and the Law of Dynamic Polarisation. Without their equivalent we will inevitably struggle to make sense of our 21st century observations within the 19th and 20th century conceptual framework we have inherited.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Neuroinformatics
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Neuron Doctrine;Law of Dynamic Polarisation;Golgi stain;Canonical cortical circuits;High-throughput circuit reconstruction
Language:English
Date:1 September 2011
Deposited On:05 Mar 2012 15:10
Last Modified:05 Apr 2016 15:42
Publisher:Springer
ISSN:1539-2791
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s12021-011-9106-1
Permanent URL: http://doi.org/10.5167/uzh-60639

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