Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Thipyapong, K; Uehara, T; Tooyama, Y; Braband, H; Alberto, R; Arano, Y (2011). Insight into Technetium Amidoxime Complex: Oxo Technetium(V) Complex of N-Substituted Benzamidoxime as New Basic Structure for Molecular Imaging. Inorganic Chemistry, 50(3):992-998.

Full text not available from this repository.

View at publisher


In search of benzamidoxime (BHam) derivatives that provide a single (99m)Tc-labeled compound of high in vivo stability, we synthesized three N-alkyl compounds of benzamidoxime (BHam) ligand. They provided a single (99m)Tc-labeled compound by ligand exchange reaction of (99m)Tc-glucoheptonate in high radiochemical yields (over 95% at MBHam concentration of 1 x 10(-5) M). (99m)Tc-N-methyl benzamidoxime ((99m)Tc-MBHam) showed higher stability than the parental (99m)Tc-BHam. The complex of this compound with (99g)TcO(3+) ion was prepared, isolated, and characterized by FT-IR and NMR spectra as well as X-ray diffraction. (99g)Tc-MBHam crystallized in an orthorhombic space group Pna2(1) with a = 13.4823(5), b = 15.5410(7), c = 7.7907(3) angstrom, V = 1632.39(11) angstrom(3), and Z = 4. The (99g)Tc complex possessed square base pyramid coordination geometry. The equatorial plane was formed by two-amine nitrogen and two-oxime oxygen atoms in trans position, while the oxo core of the technetium(V) occupied the apical position. The (99g)Tc-MBHam proved to be identical with the (99m)Tc-MBHam prepared at the no-carrier-added level by comparison of their HPLC profiles.


8 citations in Web of Science®
9 citations in Scopus®
Google Scholar™


Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Date:February 2011
Deposited On:12 Mar 2012 17:03
Last Modified:05 Apr 2016 15:42
Publisher:American Chemical Society
Publisher DOI:10.1021/ic101714q
Other Identification Number:ISI:000286688700038

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page