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Analysis of drugs of abuse in hair: Evaluation of the immunochemical method VMA-T vs. LC-MS/MS or GC-MS


Baumgartner, Markus R; Guglielmello, Rosetta; Fanger, Monique; Kraemer, Thomas (2012). Analysis of drugs of abuse in hair: Evaluation of the immunochemical method VMA-T vs. LC-MS/MS or GC-MS. Forensic Science International, 215(1-3):56-59.

Abstract

Hair analysis is an elaborate and time-consuming multi-step process. The immunometric test VMA-T from Comedical has been evaluated as screening assay for hair analysis. From routine work, authentic samples were selected that were positive for opiates, cocaine, MDMA-type drugs, amphetamines, methadone or THC. These hair samples were investigated by LC-MS or GC-MS and the VMA-T procedure, respectively. Using the cut-off values recommended by the Society of Hair Testing, the VMA-T method discriminates with good sensitivity between negative and positive hair samples and is an expedient screening method for drugs in keratinized matrices such as hair. In order to save time and resources, the residue of the VMA-T extraction solution can be reused for confirmation analysis by LC-MS except for cocaine.

Hair analysis is an elaborate and time-consuming multi-step process. The immunometric test VMA-T from Comedical has been evaluated as screening assay for hair analysis. From routine work, authentic samples were selected that were positive for opiates, cocaine, MDMA-type drugs, amphetamines, methadone or THC. These hair samples were investigated by LC-MS or GC-MS and the VMA-T procedure, respectively. Using the cut-off values recommended by the Society of Hair Testing, the VMA-T method discriminates with good sensitivity between negative and positive hair samples and is an expedient screening method for drugs in keratinized matrices such as hair. In order to save time and resources, the residue of the VMA-T extraction solution can be reused for confirmation analysis by LC-MS except for cocaine.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Legal Medicine
Dewey Decimal Classification:340 Law
610 Medicine & health
Language:English
Date:2012
Deposited On:10 Apr 2012 07:46
Last Modified:05 Apr 2016 15:43
Publisher:Elsevier
ISSN:0379-0738
Publisher DOI:10.1016/j.forsciint.2011.08.025
PubMed ID:22019396
Permanent URL: http://doi.org/10.5167/uzh-60730

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