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Campylobacter N-glycan presenting Salmonella Typhimurium: a new vaccine for broiler chickens?


Thommen, I N. Campylobacter N-glycan presenting Salmonella Typhimurium: a new vaccine for broiler chickens? 2011, University of Zurich, Vetsuisse Faculty.

Abstract

Campylobacteriosis is an emerging foodborne enteric disease in humans worldwide. Poultry meat is an important source of infection. One strategy in the combat against Campylobacter at production level is the vaccination of broiler chickens. In this study, a Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) strain was modified and used as a vector to express the N-glycan from Campylobacter on its surface. The immunogenicity of this live vaccine was tested per os in 70 commercial broilers. The vaccine was able to colonize broilers without causing disease. No detectable humoral immune response and no reduction of colonization of C. jejuni in the caeca was observed due to vaccination, however the chickens produced antibodies against the Campylobacter N-glycan upon infection with the Campylobacter jejuni challenge strain.

Campylobacteriosis is an emerging foodborne enteric disease in humans worldwide. Poultry meat is an important source of infection. One strategy in the combat against Campylobacter at production level is the vaccination of broiler chickens. In this study, a Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) strain was modified and used as a vector to express the N-glycan from Campylobacter on its surface. The immunogenicity of this live vaccine was tested per os in 70 commercial broilers. The vaccine was able to colonize broilers without causing disease. No detectable humoral immune response and no reduction of colonization of C. jejuni in the caeca was observed due to vaccination, however the chickens produced antibodies against the Campylobacter N-glycan upon infection with the Campylobacter jejuni challenge strain.

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Additional indexing

Item Type:Dissertation
Referees:Hoop R K, Stephan R
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Bacteriology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2011
Deposited On:15 Mar 2012 22:35
Last Modified:05 Apr 2016 15:43
Number of Pages:45
Related URLs:http://opac.nebis.ch/F/?local_base=NEBIS&CON_LNG=GER&func=find-b&find_code=SYS&request=006967789
Permanent URL: https://doi.org/10.5167/uzh-60771

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