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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-60878

Marruchella, G; Ligios, C; Albanese, V; Cancedda, M G; Madau, L; Lalatta-Costerbosa, G; Mazzoni, M; Clavenzani, P; Chiocchetti, R; Sarli, G; De Grossi, L; Agrimi, U; Aguzzi, A; Di Guardo, G (2007). Enteroglial and neuronal involvement without apparent neuron loss in ileal enteric nervous system plexuses from scrapie-affected sheep. Journal of General Virology, 88(Pt 10):2899-2904.

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The enteric nervous system (ENS) probably plays a dominant role in sheep scrapie pathogenesis, but little is known about the cell types involved. We investigated the ileal myenteric and submucosal plexuses of four naturally and four orally experimentally scrapie-affected ARQ/ARQ Sarda sheep, as well as those of 12 healthy-control Sarda sheep carrying different PrP genotypes. All scrapie-affected animals, euthanized at clinical-disease end stage, showed PrPd deposition within enteric glial cells (EGCs) and calbindin-immunoreactive (CALB-IR) and neuronal nitric oxide synthase (nNOS)-IR neurons. Whole-mount investigations revealed no significant differences between the densities of total, CALB-IR and nNOS-IR neurons in scrapie-affected versus healthy sheep, irrespective of PrP genotype. Our results suggest that EGCs and CALB-IR and nNOS-IR neurons are probably involved in the pathogenesis of natural and oral experimental sheep scrapie. Furthermore, the infectious agent may be less pathogenic towards ENS neurons than it is towards central nervous system neurons.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
DDC:570 Life sciences; biology
610 Medicine & health
Deposited On:02 Jul 2012 13:31
Last Modified:23 Dec 2013 14:05
Publisher:Society for General Microbiology
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:10.1099/vir.0.82907-0
PubMed ID:17872545
Citations:Web of Science®. Times Cited: 12
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Scopus®. Citation Count: 15

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