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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-61240

Husmann, M; Thalhammer, C; Spring, S; Meier, T; Roffi, M; Schwarz, U; Rousson, V; Amann-Vesti, B R (2012). Influence of plaque volume on hemodynamic response and stress hormone release in patients undergoing carotid artery stenting. International Angiology, 31(1):10-15.

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Abstract

AIM:
Carotid artery stenting (CAS) may cause bradycardia and hypotension due to barostimulation. The impact of periprocedural hypotension on CAS outcome remains controversial. The role of carotid plaque volume and catecholamine hormone release during CAS on hemodynamic changes has not been investigated so far. The aim of this prospective study was to evaluate if carotid artery plaque characteristics are predictive for stress hormone release or for postprocedural hemodynamic instability.
METHODS:
In 26 patients undergoing CAS, carotid plaque volume and morphology were assessed by two- and three-dimensional (3D)-Duplex sonography prior to the procedure. Arterial plasma adrenaline, noradrenaline and renin concentrations were measured at the time of sheath insertion and 5 minutes after stent placement. ECG, heart rate, and invasive blood pressure were monitored throughout the procedure.
RESULTS:
CAS caused no significant changes in hormone release, but increasing plaque volume was related to the degree of bradycardia following stent deployment (r=0.57; P=0.01). Plaque size was not associated with postprocedural hypotension. Plaque echogenicity (echolucent, heterogeneous or echogenic) did not correlate with changes in systolic blood pressure, heart rate or catecholamine hormone release.
CONCLUSION:
CAS caused bradycardia in relation to plaque size, but did not cause catecholamine release which may indicate that the endovascular procedure is not associated with a relevant stress reaction.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Angiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
DDC:610 Medicine & health
Language:English
Date:2012
Deposited On:16 Apr 2012 08:52
Last Modified:21 Dec 2013 21:32
Publisher:Minerva Medica
ISSN:0392-9590
Official URL:http://www.minervamedica.it/en/journals/international-angiology/article.php?cod=R34Y2012N01A0010
PubMed ID:22330619
Citations:Web of Science®
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