Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-6167

Buchmann, A; Montadori, C R A; Hänggi, Jürgen; Aerni, A; Vrticka, P; Luechinger, Roger; Boesiger, Peter; Hock, Christoph; Nitsch, R M; de Quervain, D J F; Papassotiropoulos, A; Henke, K (2008). Prion protein M129V polymorphism affects retrieval-related brain activity. Neuropsychologia, 46(9):2389-2402.

[img] PDF (Original Publication) - Registered users only
View at publisher


The prion protein Met129Val polymorphism has recently been related to human long-term memory with carriers of either the 129MM or the 129MV genotype recalling 17% more words than 129VV carriers at 24 h following learning. Here, we sampled genotype differences in retrieval-related brain activity at 30 min and 24 h following learning. Furthermore, genotype groups were compared regarding grey matter concentrations and cognitive profiles. We used event-related functional magnetic resonance imaging (fMRI) during a word recognition task on 12 Met/Met carriers, 12 Val/Met carriers, and 12 Val/Val carriers. These groups were matched for retrieval performance, gender, age, education, and other memory-related genetic polymorphisms. Although retrieval performance was matched, Val carriers exhibited enhanced retrieval-related brain activity at 30 min and 24 h following learning. At both time lags, correlations between retrieval-related brain activity and retrieval success were negative for Val homozygotes (the more activity, the worse retrieval success), while correlations showed no significance or were positive for Met homozygotes and heterozygotes. These results suggest a less economic use of retrieval-related neural resources in Val relative to Met carriers. Furthermore, Val carriers exhibited higher neocortical grey matter concentrations compared to Met carriers. When controlling for grey matter concentration, genotype effects in retrieval-related brain activity remained significant. Val and Met carriers yielded comparable brain activations for correct rejections of non-studied words and for working memory, which speaks to the specificity of the genotype effect. Findings suggest that the prion protein Met129Val polymorphism affects neural plasticity following learning at a time-scale of minutes to hours.


6 citations in Web of Science®
7 citations in Scopus®
Google Scholar™



4 downloads since deposited on 27 Nov 2008
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Division of Psychiatric Research and Clinic for Psychogeriatric Medicine
04 Faculty of Medicine > Institute of Biomedical Engineering
06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:150 Psychology
170 Ethics
610 Medicine & health
Deposited On:27 Nov 2008 12:22
Last Modified:05 Apr 2016 12:36
Publisher DOI:10.1016/j.neuropsychologia.2008.03.002
PubMed ID:18423780

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page