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Quantitative J-resolved prostate spectroscopy using two-dimensional prior-knowledge fitting


Langenegger, T; Schulte, R F; Boesiger, P (2008). Quantitative J-resolved prostate spectroscopy using two-dimensional prior-knowledge fitting. Magnetic Resonance in Medicine, 59(5):966-972.

Abstract

Two-dimensional (2D) prior-knowledge fitting (ProFit) was adapted and applied for the quantification of J-resolved (JPRESS) spectra acquired at a field strength of 3T from the human prostate in vivo. In contrast to methods based on simple line fitting and peak integration, commonly applied for metabolite quantification in the prostate, ProFit yields metabolite concentration ratios that are independent of sequence and field strength, since it is based on the linear combination of 2D basis spectra. It is demonstrated that ProFit benefits from the increased information content and reduced baseline distortion in JPRESS prostate spectra, in particular for the quantification of coupled metabolites like citrate (Cit), spermine (Spm), and myo-inositol (mI). The method is validated with 10 repetitive prostate measurements on the same subject. Furthermore, a study carried out on 10 healthy subjects shows that the six prostate metabolites creatine (Cr), total choline (Cho), Cit, Spm, mI, and scyllo-inositol (sI) can be reliably detected in vivo, some of which--especially total Cho and Cit--have proven to be useful markers for the detection of prostate cancer.

Two-dimensional (2D) prior-knowledge fitting (ProFit) was adapted and applied for the quantification of J-resolved (JPRESS) spectra acquired at a field strength of 3T from the human prostate in vivo. In contrast to methods based on simple line fitting and peak integration, commonly applied for metabolite quantification in the prostate, ProFit yields metabolite concentration ratios that are independent of sequence and field strength, since it is based on the linear combination of 2D basis spectra. It is demonstrated that ProFit benefits from the increased information content and reduced baseline distortion in JPRESS prostate spectra, in particular for the quantification of coupled metabolites like citrate (Cit), spermine (Spm), and myo-inositol (mI). The method is validated with 10 repetitive prostate measurements on the same subject. Furthermore, a study carried out on 10 healthy subjects shows that the six prostate metabolites creatine (Cr), total choline (Cho), Cit, Spm, mI, and scyllo-inositol (sI) can be reliably detected in vivo, some of which--especially total Cho and Cit--have proven to be useful markers for the detection of prostate cancer.

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15 citations in Web of Science®
18 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2008
Deposited On:04 Dec 2008 11:51
Last Modified:05 Apr 2016 12:36
Publisher:Wiley-Blackwell
ISSN:0740-3194
Publisher DOI:10.1002/mrm.21438
PubMed ID:18429013
Permanent URL: http://doi.org/10.5167/uzh-6170

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