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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-62296

Soyka, Jan D; Muster, Marco A; Schmid, Daniel T; Seifert, Burkhardt; Schick, Ulrike; Miralbell, Raymond; Jorcano, Sandra; Zaugg, Kathrin; Seifert, Hans-Helge; Veit-Haibach, Patrick; Strobel, Klaus; Schaefer, Niklaus G; Husarik, Daniela B; Hany, Thomas F (2012). Clinical impact of (18)F-choline PET/CT in patients with recurrent prostate cancer. European Journal of Nuclear Medicine and Molecular Imaging, 39(6):936-943.

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Abstract

PURPOSE: To investigate the clinical value of (18)F-fluorocholine PET/CT (CH-PET/CT) in treatment decisions in patients with recurrent prostate cancer (rPCA).

METHODS: The study was a retrospective evaluation of 156 patients with rPCA and CH-PET/CT for restaging. Questionnaires for each examination were sent to the referring physicians 14-64 months after examination. Questions included information regarding initial extent of disease, curative first-line treatment, and the treatment plan before and after CH-PET/CT. Additionally, PSA values at diagnosis, after initial treatment, before CH-PET/CT and at the end of follow-up were also obtained from the questionnaires.

RESULTS: Mean follow-up was 42 months. The mean Gleason score was 6.9 at initial diagnosis. Initial treatment was: radical prostatectomy in 110 patients, radiotherapy in 39, and combined prostatectomy and radiotherapy in 7. Median PSA values before CH-PET/CT and at the end of follow-up were 3.40 ng/ml and 0.91 ng/ml. PSA levels remained stable, decreased or were below measurable levels in 108 patients. PSA levels increased in 48 patients. In 75 of the 156 patients (48%) the treatment plan was changed due to the CH-PET/CT findings. In 33 patients the therapeutic plan was changed from palliative treatment to treatment with curative intent. In 15 patients treatment was changed from curative to palliative. In 8 patients treatment was changed from curative to another strategy and in 2 patients from one palliative strategy to another. In 17 patients the treatment plan was adapted.

CONCLUSION: CH-PET/CT has an important impact on the therapeutic strategy in patients with rPCA and can help to determine an appropriate treatment.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology
04 Faculty of Medicine > Epidemology, Biostatistics and Prevention Institute (EBPI)
DDC:610 Medicine & health
Language:English
Date:2012
Deposited On:21 May 2012 11:51
Last Modified:17 May 2014 17:47
Publisher:Springer
ISSN:1619-7070
Additional Information:The final publication is available at www.springerlink.com
Publisher DOI:10.1007/s00259-012-2083-2
PubMed ID:22415598
Citations:Web of Science®. Times Cited: 18
Google Scholar™
Scopus®. Citation Count: 24

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