Quick Search:

is currently disabled due to reindexing of the ZORA database. Please use Advanced Search.
uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-62428

Dill, P; Wagner, M; Somerville, A; Thöny, B; Blau, N; Weber, P (2012). Child neurology: paroxysmal stiffening, upward gaze, and hypotonia: hallmarks of sepiapterin reductase deficiency. Neurology, 78(5):e29-32.

[img]Published Version
PDF - Registered users only
371kB

Abstract

Sepiapterin reductase deficiency (SRD) is a dopa-sensitive neurotransmitter disorder, caused by mutation of the SPR gene located on chromosome 2p14-p12.1 To date, 31 patients with 14 mutations have been diagnosed (BIODEF database, update November 2010, www.biopku.org).

While classic tetrahydrobiopterin deficiencies present with hyperphenylalaninemia and deficiency of monoamine neurotransmitters, SRD is typically associated with normal phenylalanine levels in blood and pterins in urine2 and not detectable by neonatal screening for phenylketonuria. This implies how important it is to diagnose this condition clinically, in order to provide timely and proper treatment. A summary of the pathophysiology and biochemical pathway is provided by Bonafé et al.

With the following case report and review of 21 published cases, we elucidate the clinical features of SRD as well as the diagnostic strategy and therapeutic approach.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
04 Faculty of Medicine > Center for Integrative Human Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Date:2012
Deposited On:21 May 2012 11:05
Last Modified:30 Nov 2013 18:37
Publisher:Lippincott Wiliams & Wilkins
ISSN:0028-3878
Funders:Swiss National Science Foundation (3100A0-1199852/1)
Publisher DOI:10.1212/WNL.0b013e3182452849
PubMed ID:22291068
Citations:Web of Science®. Times Cited: 2
Google Scholar™
Scopus®. Citation Count: 1

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page