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Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin.


Oldham, S; Montagne, J; Radimerski, T; Thomas, G; Hafen, E (2000). Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes and Development, 14(21):2689-2694.

Abstract

The adaptation of growth in response to nutritional changes is essential for the proper development of all organisms. Here we describe the identification of the Drosophila homolog of the target of rapamycin (TOR), a candidate effector for nutritional sensing. Genetic and biochemical analyses indicate that dTOR impinges on the insulin signaling pathway by autonomously affecting growth through modulating the activity of dS6K. However, in contrast to other components in the insulin signaling pathway, partial loss of dTOR function preferentially reduces growth of the endoreplicating tissues. These results are consistent with dTOR residing on a parallel amino acid sensing pathway.

The adaptation of growth in response to nutritional changes is essential for the proper development of all organisms. Here we describe the identification of the Drosophila homolog of the target of rapamycin (TOR), a candidate effector for nutritional sensing. Genetic and biochemical analyses indicate that dTOR impinges on the insulin signaling pathway by autonomously affecting growth through modulating the activity of dS6K. However, in contrast to other components in the insulin signaling pathway, partial loss of dTOR function preferentially reduces growth of the endoreplicating tissues. These results are consistent with dTOR residing on a parallel amino acid sensing pathway.

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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Zoology (former)
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Language:English
Date:1 November 2000
Deposited On:11 Feb 2008 12:16
Last Modified:05 Apr 2016 12:15
Publisher:Cold Spring Harbor Laboratory Press
ISSN:0890-9369
Publisher DOI:10.1101/gad.845700
Related URLs:http://www.genesdev.org/cgi/content/abstract/14/21/2689
PubMed ID:11069885
Permanent URL: http://doi.org/10.5167/uzh-626

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