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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-6262

Wackermann, J; Wittmann, M; Hasler, F; Vollenweider, F X (2008). Effects of varied doses of psilocybin on time interval reproduction in human subjects. Neuroscience Letters, 435(1):51-55.

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Abstract

Action of a hallucinogenic substance, psilocybin, on internal time representation was investigated in two double-blind, placebo-controlled studies: Experiment 1 with 12 subjects and graded doses, and Experiment 2 with 9 subjects and a very low dose. The task consisted in repeated reproductions of time intervals in the range from 1.5 to 5s. The effects were assessed by parameter kappa of the 'dual klepsydra' model of internal time representation, fitted to individual response data and intra-individually normalized with respect to initial values. The estimates kappa were in the same order of magnitude as in earlier studies. In both experiments, kappa was significantly increased by psilocybin at 90 min from the drug intake, indicating a higher loss rate of the internal duration representation. These findings are tentatively linked to qualitative alterations of subjective time in altered states of consciousness.

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20 citations in Web of Science®
26 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
DDC:610 Medicine & health
Language:English
Date:11 April 2008
Deposited On:03 Jan 2009 13:34
Last Modified:23 Nov 2012 13:53
Publisher:Elsevier
ISSN:0304-3940
Publisher DOI:10.1016/j.neulet.2008.02.006
PubMed ID:18325673

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