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Decision-making dysregulation in first-episode schizophrenia


Cattapan-Ludewig, K; Ludewig, S; Messerli, N; Vollenweider, F X; Seitz, A; Feldon, J; Paulus, M P (2008). Decision-making dysregulation in first-episode schizophrenia. Journal of Nervous and Mental Disease, 196(2):157-160.

Abstract

Studies with chronic schizophrenia patients have demonstrated that patients fluctuate between rigid and unpredictable responses in decision-making situations, a phenomenon which has been called dysregulation. The aim of this study was to investigate whether schizophrenia patients already display dysregulated behavior at the beginning of their illness. Thirty-two first-episode schizophrenia or schizophreniform patients and 30 healthy controls performed the two-choice prediction task. The decision-making behavior of first-episode patients was shown to be characterized by a high degree of dysregulation accompanied by low metric entropy and a tendency towards increased mutual information. These results indicate that behavioral abnormalities during the two-choice prediction task are already present during the early stages of the illness.

Studies with chronic schizophrenia patients have demonstrated that patients fluctuate between rigid and unpredictable responses in decision-making situations, a phenomenon which has been called dysregulation. The aim of this study was to investigate whether schizophrenia patients already display dysregulated behavior at the beginning of their illness. Thirty-two first-episode schizophrenia or schizophreniform patients and 30 healthy controls performed the two-choice prediction task. The decision-making behavior of first-episode patients was shown to be characterized by a high degree of dysregulation accompanied by low metric entropy and a tendency towards increased mutual information. These results indicate that behavioral abnormalities during the two-choice prediction task are already present during the early stages of the illness.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:February 2008
Deposited On:11 Dec 2008 23:04
Last Modified:05 Apr 2016 12:36
Publisher:Lippincott Wiliams & Wilkins
ISSN:0022-3018
Publisher DOI:10.1097/NMD.0b013e318162aa1b
PubMed ID:18277225
Permanent URL: http://doi.org/10.5167/uzh-6263

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