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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-62887

Tilleman, L; Germani, F; De Henau, S; Geuens, E; Hoogewijs, D; Braeckman, B P; Vanfleteren, J R; Moens, L; Dewilde, S (2011). Globins in Caenorhabditis elegans. IUBMB Life, 63(3):166-174.

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Abstract

Extensive in silico search of the genome of Caenorhabditis elegans revealed the presence of 33 genes coding for globins that are all transcribed. These globins are very diverse in gene and protein structure and are localized in a variety of cells, mostly neurons. The large number of C. elegans globin genes is assumed to be the result of multiple evolutionary duplication and radiation events. Processes of subfunctionalization and diversification probably led to their cell-specific expression patterns and fixation into the genome. To date, four globins (GLB-1, GLB-5, GLB-6, and GLB-26) have been partially characterized physicochemically, and the crystallographic structure of two of them (GLB-1 and GLB-6) was solved. In this article, a three-dimensional model was designed for the other two globins (GLB-5 and GLB-26), and overlays of the globins were constructed to highlight the structural diversity among them. It is clear that although they all share the globin fold, small variations in the three-dimensional structure have major implications on their ligand-binding properties and possibly their function. We also review here all the information available so far on the globin family of C. elegans and suggest potential functions.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology

04 Faculty of Medicine > Center for Integrative Human Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Uncontrolled Keywords: hemeproteins; oxgen metabolism; protein function; protein structure; redox
Language:English
Date:2011
Deposited On:20 Jul 2012 11:21
Last Modified:16 Dec 2013 15:01
Publisher:Wiley-Blackwell
ISSN:1521-6543
Funders:Fund for Scientific Research (FWO), BOF UA TOP 2006, FWO project G.0247.09
Publisher DOI:10.1002/iub.443
Citations:Web of Science®. Times Cited: 2
Google Scholar™
Scopus®. Citation Count: 2

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