Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-62955

Valenta, Tomas; Hausmann, George; Basler, Konrad (2012). The many faces and functions of β-catenin. EMBO Journal, 31(12):2714-2736.

[img]Published Version (English)
PDF - Registered users only
1MB

View at publisher

Abstract

β-Catenin (Armadillo in Drosophila) is a multitasking and evolutionary conserved molecule that in metazoans exerts a crucial role in a multitude of developmental and homeostatic processes. More specifically, β-catenin is an integral structural component of cadherin-based adherens junctions, and the key nuclear effector of canonical Wnt signalling in the nucleus. Imbalance in the structural and signalling properties of β-catenin often results in disease and deregulated growth connected to cancer and metastasis. Intense research into the life of β-catenin has revealed a complex picture. Here, we try to capture the state of the art: we try to summarize and make some sense of the processes that regulate β-catenin, as well as the plethora of β-catenin binding partners. One focus will be the interaction of β-catenin with different transcription factors and the potential implications of these interactions for direct cross-talk between β-catenin and non-Wnt signalling pathways.

Citations

110 citations in Web of Science®
116 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

2 downloads since deposited on 20 Jun 2012
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Uncontrolled Keywords:β-catenin; cell adhesion; cell signalling; transcription; Wnts
Language:English
Date:22 May 2012
Deposited On:20 Jun 2012 15:08
Last Modified:30 Dec 2013 09:31
Publisher:Nature Publishing Group
ISSN:0261-4189
Publisher DOI:10.1038/emboj.2012.150
PubMed ID:22617422

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page