Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-63128

Al Ahmad, Abraham; Gassmann, Max; Ogunshola, Omolara O (2012). Involvement of oxidative stress in hypoxia-induced blood-brain barrier breakdown. Microvascular Research, 84(2):222-225.

Accepted Version
View at publisher


The blood-brain barrier (BBB) is a cellular barrier formed by specialized brain endothelial cells under the influence of astrocytes and pericytes. Among the several stress factors known to induce BBB breakdown, hypoxia is probably the most represented but also the least understood. Recent evidence of oxidative stress occurring during hypoxia/ischemia situation raises its possible contribution to barrier breakdown. In this study, we investigated the relevance of oxidative stress in hypoxia-induced barrier disruption. Prolonged hypoxic exposure induced radical oxygen species (ROS) formation and induced glutathione oxidation. Such effects were accentuated under extreme O(2) deprived environment. Pro-oxidant treatment significantly disrupted barrier function under normal conditions, whereas anti-oxidant treatment contributed to maintain better barrier function and cell survival in an O(2)-reduced environment. In addition, the endothelial response to oxidative stress appeared modulated by the presence of astrocytes and pericytes, thus explaining some of the beneficial contribution of these cells as previously described. Taken together, this study highlights the importance of oxidative stress signaling at the barrier. In addition, cells of the neurovascular compartment differentially modulate ROS levels and also regulate barrier function. Thus, use of radical scavengers may be useful to support barrier function following stroke injury.


12 citations in Web of Science®
19 citations in Scopus®
Google Scholar™



87 downloads since deposited on 06 Jul 2012
15 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
05 Vetsuisse Faculty > Institute of Veterinary Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Deposited On:06 Jul 2012 08:40
Last Modified:05 Apr 2016 15:52
Publisher DOI:10.1016/j.mvr.2012.05.008
PubMed ID:22668821

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page