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Bosch, Oliver G; Seifritz, Erich; Wetter, Thomas C (2012). Stress-related depression: Neuroendocrine, genetic, and therapeutical aspects. World Journal of Biological Psychiatry, 13(8):556-568.

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Objective. To summarize current concepts on neuroendocrine and genetic principles underlying stress-related depression and to discuss the challenges of personalized treatment in depression. Methods. Review of the literature pertaining to genetic and neuroendocrine basis of stress-related depression including aspects of treatment response with a focus on the hypothalamus-pituitary-adrenal (HPA) axis. Results. There is increasing evidence that genetic polymorphisms and dysregulation of the HPA axis are associated with the pathophysiology of stress-related depression. Individual stress hormone reactivity seems to be determined by a combination of genetic and environmental factors, contributing to both, resilience or vulnerability. Conclusions. Although substantial progress has been made, current knowledge is still limited. Further basic and clinical research is needed to identify specific subgroups and to minimize heterogeneity of the depression phenotype. A better characterization is essential to detect genetic and functional predictors of antidepressant treatment response to follow the vision of personalized therapy in psychiatry.


17 citations in Web of Science®
17 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Psychiatry, Psychotherapy, and Psychosomatics
Dewey Decimal Classification:610 Medicine & health
Date:7 June 2012
Deposited On:20 Jun 2012 14:54
Last Modified:05 Apr 2016 15:52
Publisher:Informa Healthcare
Publisher DOI:10.3109/15622975.2012.665477
PubMed ID:22676799

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