Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-63178

Dummer, R; Beyer, M; Hymes, K; Epping, M T; Bernards, R; Steinhoff, M; Sterry, W; Kerl, H; Heath, K; Ahern, J D; Hardwick, J S; Garcia-Vargas, J; Baumann, K; Rizvi, S; Frankel, S R; Whittacker, S J; Assaf, C (2012). Vorinostat combined with bexarotene for treatment of cutaneous T-cell lymphoma: in vitro and phase I clinical evidence supporting augmentation of retinoic acid receptor/retinoid X receptor activation by histone deacetylase inhibition. Leukemia and Lymphoma, 53(8):1501-1508.

[img]Published Version
PDF - Registered users only


The retinoid X receptor (RXR)-agonist bexarotene and the histone deacetylase inhibitor (HDACI) vorinostat are each established monotherapies for cutaneous T-cell lymphomas (CTCLs). We investigated the combination of HDACI and retinoic acid receptor (RAR)/RXR agonists in vitro and in a phase I, multicenter, open-label, two-part dose-escalation study. The combination of bexarotene with a HDACI in vitro leads to cooperative activation of gene transcription and reduction of cell viability in human tumor cell lines. The primary clinical objective was to determine the maximum tolerated dose (MTD) of bexarotene plus vorinostat in 23 patients with CTCLs. The MTD for part I was established at vorinostat 200 mg/day plus bexarotene 300 mg/m 2 /day. The
MTD for part II was not reached. Four patients had an active response and seven patients experienced pruritus relief. We conclude that concomitant administration of vorinostat and bexarotene is feasible only if lower doses of each drug are administered relative to the product label monotherapy doses.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
DDC:610 Medicine & health
Date:8 January 2012
Deposited On:09 Jul 2012 09:00
Last Modified:06 Jan 2014 18:15
Publisher:Informa Healthcare
Publisher DOI:10.3109/10428194.2012.656625
PubMed ID:22239668
Citations:Web of Science®. Times Cited: 8
Google Scholar™
Scopus®. Citation Count: 9

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page