UZH-Logo

Prolactin – to be reconsidered in canine mammary tumorigenesis?


Michel, Erika; Rohrer Bley, Carla; Kowalewski, Mariusz; Feldmann, Stefanie; Reichler, Iris (2014). Prolactin – to be reconsidered in canine mammary tumorigenesis? Veterinary and Comparative Oncology, 12(2):93-105.

Abstract

Mammary tumors represent the most common neoplastic disease of the female dog, and the incidence in female dogs is much higher than in women. Whereas the influence of sexual steroids on breast cancer development in dogs has been studied, very little is known about the role of prolactin. New studies show that until recently, the importance of prolactin in human breast cancer development and progression has been highly underestimated. Prolactin plays a role in promoting benign as well as malignant neoplastic cell growth in breast cancer in vitro and in vivo. Sporadic publications proposed a tumor promotor role in the dog. The goal of this review is to summarize our knowledge about prolactin and human breast cancer as well as canine mammary tumorigenesis, and propose future research in this area.

Mammary tumors represent the most common neoplastic disease of the female dog, and the incidence in female dogs is much higher than in women. Whereas the influence of sexual steroids on breast cancer development in dogs has been studied, very little is known about the role of prolactin. New studies show that until recently, the importance of prolactin in human breast cancer development and progression has been highly underestimated. Prolactin plays a role in promoting benign as well as malignant neoplastic cell growth in breast cancer in vitro and in vivo. Sporadic publications proposed a tumor promotor role in the dog. The goal of this review is to summarize our knowledge about prolactin and human breast cancer as well as canine mammary tumorigenesis, and propose future research in this area.

Citations

1 citation in Web of Science®
1 citation in Scopus®
Google Scholar™

Altmetrics

Downloads

2 downloads since deposited on 10 Jul 2012
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Anatomy
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2014
Deposited On:10 Jul 2012 08:34
Last Modified:05 Apr 2016 15:52
Publisher:Wiley-Blackwell
ISSN:1476-5810
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1111/j.1476-5829.2012.00337.x
PubMed ID:22738741
Permanent URL: http://doi.org/10.5167/uzh-63237

Download

[img]
Content: Accepted Version
Filetype: PDF - Registered users only
Size: 249kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations