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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-63237

Michel, Erika; Rohrer Bley, Carla; Kowalewski, Mariusz; Feldmann, Stefanie; Reichler, Iris (2014). Prolactin – to be reconsidered in canine mammary tumorigenesis? Veterinary and Comparative Oncology, 12(2):93-105.

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Mammary tumors represent the most common neoplastic disease of the female dog, and the incidence in female dogs is much higher than in women. Whereas the influence of sexual steroids on breast cancer development in dogs has been studied, very little is known about the role of prolactin. New studies show that until recently, the importance of prolactin in human breast cancer development and progression has been highly underestimated. Prolactin plays a role in promoting benign as well as malignant neoplastic cell growth in breast cancer in vitro and in vivo. Sporadic publications proposed a tumor promotor role in the dog. The goal of this review is to summarize our knowledge about prolactin and human breast cancer as well as canine mammary tumorigenesis, and propose future research in this area.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Anatomy
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Clinic for Reproductive Medicine
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals > Division of Radiation Oncology
DDC:570 Life sciences; biology
630 Agriculture
Deposited On:10 Jul 2012 08:34
Last Modified:09 Apr 2014 06:34
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1111/j.1476-5829.2012.00337.x
PubMed ID:22738741
Citations:Web of Science®
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