Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-63237
Michel, Erika; Rohrer Bley, Carla; Kowalewski, Mariusz; Feldmann, Stefanie; Reichler, Iris (2014). Prolactin – to be reconsidered in canine mammary tumorigenesis? Veterinary and Comparative Oncology, 12(2):93-105.
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Mammary tumors represent the most common neoplastic disease of the female dog, and the incidence in female dogs is much higher than in women. Whereas the influence of sexual steroids on breast cancer development in dogs has been studied, very little is known about the role of prolactin. New studies show that until recently, the importance of prolactin in human breast cancer development and progression has been highly underestimated. Prolactin plays a role in promoting benign as well as malignant neoplastic cell growth in breast cancer in vitro and in vivo. Sporadic publications proposed a tumor promotor role in the dog. The goal of this review is to summarize our knowledge about prolactin and human breast cancer as well as canine mammary tumorigenesis, and propose future research in this area.
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||05 Vetsuisse Faculty > Institute of Veterinary Anatomy|
05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals > Clinic for Reproductive Medicine
05 Vetsuisse Faculty > Veterinary Clinic > Department of Small Animals > Division of Radiation Oncology
|DDC:||570 Life sciences; biology|
|Deposited On:||10 Jul 2012 10:34|
|Last Modified:||09 Apr 2014 08:34|
|Free access at:||Publisher DOI. An embargo period may apply.|
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