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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-6329

Hennet, T (2009). From glycosylation disorders back to glycosylation: what have we learned? Biochimica et Biophysica Acta, 1792(9):921-924.

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Diseases of glycosylation have long remained confined to the rare hematological disorders, the Tn-syndrome [1] and paroxysmal nocturnal hemoglobinuria [2]. This rarity was often interpreted as a sign that defects of glycosylation are either lethal, or remain asymptomatic because of the large redundancy found in glycosylation pathways. The description of multiple glycosylation disorders over the last years has definitively settled the issue and demonstrated the broad range of biological processes relying on proper glycosylation. However, beyond establishing the developmental and physiological roles of glycosylation how did glycosylation disorders contribute to new insights in the field of glycobiology?


7 citations in Web of Science®
7 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:September 2009
Deposited On:02 Dec 2008 12:31
Last Modified:05 Apr 2016 12:36
Publisher DOI:10.1016/j.bbadis.2008.10.006
PubMed ID:19007883

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